EU Adds 23 Substances to List of Hazardous Chemicals Banned for Use in Cosmetics

The European Commission (EC) recently expanded its list of substances to be banned under its Cosmetics Regulation 1223/2009. As of March 1, 2022, 23 additional chemical substances (designated as carcinogenic, mutagenic, or reprotoxic) will be prohibited in line with Article 15 of the Regulation. Here we take a look at the Cosmetics Regulation and review the newly added chemicals.

European Commission Regulation 1223/2009 on Cosmetics

The European Commission Regulation 1223/2009 on cosmetics is the principal regulation established for cosmetic products in the European Union. Enacted in July 2013, it replaces previous cosmetics-focused EU directives, including European Council Directive 76/768/EEC. With a focus on many aspects related to cosmetic products (from manufacturing onward), the ultimate goal of the Regulation is to help ensure the health and safety of individuals in the EU.

More detailed information about European Commission Regulation 1223/2009 may be found on the EUR-Lex website.

23 Additional CMR Chemicals

CMR chemicals refer to ones that are carcinogenic, mutagenic, or reprotoxic.

  • Carcinogens -- Substances that have the ability to cause (or increase the incidence of) cancer
  • Mutagens -- Substances that can cause or promote genetic defects
  • Reprotoxins -- Substances that have the ability to adversely affect the reproductive process (in males and females)

The 23 CMR chemical substances added to the EC's prohibited substance list are displayed in the table below.

Substance NameCAS NumberEC Number
Silicon carbide fibers (with diameter < 3 µm, length > 5 µm, and aspect ratio = 3:1)409-21-2; 308076-74-6206-991-8
Tris(2-methoxyethoxy) vinylsilane; 6-(2-methoxyethoxy)- 6-vinyl-2,5,7,10-tetraoxa-6-silaundecane1067-53-4213-934-0
Dioctyltin dilaurate [1]; stannane, dioctyl-, bis (coco acyloxy) derivs. [2]3648-18-8 [1]; 91648-39-4 [2]222-883-3 [1]; 293-901-5 [2]
Dibenzo[def,p]chrysene; dibenzo[a,l]pyrene191-30-0205-886-4
Ipconazole (ISO); (1RS,2SR,5RS;1RS,2SR,5SR)-2-(4-chlorobenzyl)-5-isopropyl-1- (1H-1,2,4-triazol-1-ylmethyl)cyclopentanol125225-28-7; 115850-69-6; 115937-89-8--
Bis(2-(2-methoxyethoxy)ethyl)ether; tetraglyme143-24-8205-594-7
Paclobutrazol (ISO); (2RS,3RS)-1-(4-chlorophenyl)-4,4-dimethyl- 2-(1H-1,2,4-triazol-1- yl)pentan-3-ol76738-62-0--
2,2-bis(bromomethyl) propane-1,3-diol3296-90-0221-967-7
2-(4-tert-butylbenzyl) propionaldehyde80-54-6201-289-8
Diisooctyl phthalate27554-26-3248-523-5
2-methoxyethyl acrylate3121-61-7221-499-3
Sodium N-(hydroxymethyl)glycinate; [formaldehyde released from sodium N-(hydroxymethyl)glycinate] if maximum theoretical concentration of releasable formaldehyde, in mixture as placed on market is = 0,1 % w/w70161-44-3274-357-8
Pyrithione zinc; (T-4)- bis[1-(hydroxy-.kappa.O)pyridine-2(1H)- thionato-.kappa.S]zinc13463-41-7236-671-3
Flurochloridone (ISO); 3-chloro-4-(chloromethyl)-1-[3-(trifluoromethyl)phenyl]pyrrolidin-2-one61213-25-0262-661-3
3-(difluoromethyl)-1- methyl-N-(3',4',5'-trifluorobiphenyl-2-yl) pyrazole-4-carboxamide; fluxapyroxad907204-31-3--
N-(hydroxymethyl)acrylamide; methylolacrylamide; [NMA]924-42-5213-103-2
5-fluoro-1,3-dimethyl-N-[2-(4- methylpentan-2-yl) phenyl]-1H-pyrazole- 4-carboxamide; 2'- [(RS)-1,3-dimethylbutyl]-5-fluoro-1,3-dimethylpyrazole-4-carboxanilide; penflufen494793-67-8--
Iprovalicarb (ISO); isopropyl [(2S)-3- methyl-1-{[1-(4- methylphenyl)ethyl] amino}-1-oxobutan-2- yl]carbamate140923-17-7--
Mesotrione (ISO); 2-[4-(methylsulfonyl)- 2-nitrobenzoyl]-1,3- cyclohexanedione104206-82-8--
Hymexazol (ISO); 3-hydroxy-5-methylisoxazole10004-44-1233-000-6
Imiprothrin (ISO); reaction mass of: [2,4- dioxo-(2-propyn-1-yl) imidazolidin-3-yl] methyl(1R)-cis-chrysanthemate; [2,4-dioxo-(2-propyn-1-yl) imidazolidin-3-yl] methyl(1R)-trans-chrysanthemate72963-72-5428-790-6
Bis(a,a-dimethylbenzyl) peroxide80-43-3201-279-3

Source: European Commission

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